/* ResusDoc — Drug Monographs. Tokens lifted from Resusdoc/index.html (landing V3). */
*{box-sizing:border-box;margin:0;padding:0}
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html,body{overflow-x:clip}
html{scroll-behavior:smooth;scroll-padding-top:88px}
body{font-family:var(--sans);color:var(--ink);background:var(--bg);
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.wrap{max-width:1120px;margin:0 auto;padding:0 24px}
a{color:var(--turq-strong);text-decoration-thickness:1px;text-underline-offset:2px}
a:focus-visible,button:focus-visible,input:focus-visible{outline:2px solid var(--focus);outline-offset:2px;border-radius:4px}
.skip{position:absolute;left:-9999px}
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.mono{font-family:var(--mono)}

/* ---------- top bar ---------- */
.topbar{position:sticky;top:0;z-index:40;background:rgba(255,255,255,.88);
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.rd-mark .nm-cross{fill:var(--turq-strong);stroke:none}
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.tb nav{display:flex;gap:22px;font-size:14.5px;font-weight:500}
.tb nav a{color:var(--ink2);text-decoration:none}
.tb nav a:hover,.tb nav a.on{color:var(--turq-strong)}

/* ---------- disclaimer ---------- */
.disc{background:var(--red-tint);border-bottom:1px solid rgba(193,50,57,.18)}
.disc-w{display:flex;align-items:center;gap:12px;padding-top:11px;padding-bottom:11px}
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.disc-x:hover{opacity:1}

/* ---------- hero ---------- */
.hero{background:linear-gradient(180deg,var(--turq-tint) 0%,var(--bg1) 55%,var(--bg) 100%);
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.hero-idx{padding:64px 0 56px}
.eyebrow,.crumb{font-family:var(--mono);font-size:12px;letter-spacing:.08em;
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.crumb a{text-decoration:none}
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.hero h1{font-size:clamp(34px,6vw,54px);line-height:1.04;letter-spacing:-.035em;font-weight:700}
.hero-sub{margin-top:16px;max-width:68ch;font-size:clamp(16.5px,2vw,19px);color:var(--ink2);line-height:1.6}
.cnt{margin-top:20px;font-size:13.5px;color:var(--ink3)}
.cnt .mono{color:var(--turq-strong);font-weight:600}
.tags{display:flex;flex-wrap:wrap;gap:8px;margin-top:20px}
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/* ---------- at a glance ---------- */
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.kv-v{font-size:15.5px;font-weight:500;line-height:1.45}

/* ---------- two-column layout ---------- */
.cols{display:grid;grid-template-columns:212px minmax(0,1fr);gap:56px;
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.toc{position:sticky;top:88px}
.toc-h{font-family:var(--mono);font-size:11px;letter-spacing:.08em;text-transform:uppercase;
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.toc ol{list-style:none;counter-reset:t}
.toc li{counter-increment:t;margin-bottom:2px}
.toc a{display:block;font-size:13.5px;line-height:1.4;padding:6px 10px 6px 30px;
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  transition:background .18s var(--ease),color .18s var(--ease)}
.toc a::before{content:counter(t,decimal-leading-zero);position:absolute;left:10px;
  font-family:var(--mono);font-size:10.5px;color:var(--turq);top:8px}
.toc a:hover{background:var(--turq-tint);color:var(--turq-strong)}

/* ---------- article body ---------- */
.body{min-width:0}
.sec{margin-bottom:52px;scroll-margin-top:88px}
.sec h2{font-size:clamp(23px,3vw,29px);letter-spacing:-.02em;line-height:1.2;
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.body h3{font-size:18px;letter-spacing:-.01em;margin:32px 0 12px;color:var(--turq-strong);scroll-margin-top:88px}
.body p{margin-bottom:16px;color:var(--ink2)}
.body p strong,.body li strong{color:var(--ink);font-weight:600}
.body ul,.body ol{margin:0 0 18px 22px;color:var(--ink2)}
.body li{margin-bottom:8px;padding-left:4px}
.body ul li::marker{color:var(--turq)}
.body ol li::marker{color:var(--turq-strong);font-family:var(--mono);font-size:.9em}
code{font-family:var(--mono);font-size:.88em;background:var(--turq-tint);color:var(--turq-strong);
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sup.ref{font-family:var(--mono);font-size:10.5px;font-weight:500;vertical-align:super;line-height:0}
sup.ref a{text-decoration:none;padding:0 1px}
sup.ref a:hover{text-decoration:underline}

/* definition list */
.dl{margin-bottom:20px}
.dl-row{display:grid;grid-template-columns:150px minmax(0,1fr);gap:16px;padding:11px 0;
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.dl-row dt{font-weight:600;font-size:14.5px;color:var(--ink)}
.dl-row dd{color:var(--ink2);font-size:15.5px}

/* tables */
.tw{overflow-x:auto;margin:0 0 22px;border:1px solid var(--border2);
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table{width:100%;border-collapse:collapse;font-size:14.5px;background:#fff;min-width:460px}
caption{caption-side:top;text-align:left;padding:14px 18px 10px;font-size:13px;
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thead th{background:var(--turq-tint);color:var(--turq-strong);text-align:left;
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tbody td,tbody th{padding:12px 16px;border-top:1px solid var(--border);
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tbody th{font-weight:600;color:var(--ink)}
tbody tr:nth-child(even){background:var(--bg1)}

/* callouts */
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.co svg{width:20px;height:20px;flex:none;margin-top:2px}
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.co-t{font-weight:600;margin-bottom:6px!important;color:inherit;font-size:15.5px}
.co p{font-size:15px;line-height:1.6}
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.co-warn p{color:#7A4700}
.co-danger{background:var(--red-tint);border-color:rgba(193,50,57,.25);color:var(--red-deep)}
.co-danger p{color:#7A2429}
.co-exam{background:var(--bg2);border-color:var(--border3);color:var(--ink)}
.co-exam p{color:var(--ink2)}

blockquote{border-left:3px solid var(--turq);background:var(--bg1);padding:16px 20px;
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blockquote p{font-style:italic;margin-bottom:6px}
blockquote cite{font-family:var(--mono);font-size:12.5px;color:var(--ink3);font-style:normal}

/* references */
.refs{list-style:none;margin:0;font-size:14.5px}
.refs li{display:flex;gap:14px;padding:12px 0;border-bottom:1px solid var(--border);
  color:var(--ink2);line-height:1.55;scroll-margin-top:88px}
.refs li:target{background:var(--turq-tint);border-radius:var(--r-sm);
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.rn{font-family:var(--mono);font-size:12px;color:var(--turq-strong);flex:none;
  width:24px;text-align:right;padding-top:2px;font-weight:600}
.meta{font-family:var(--mono);font-size:12.5px;color:var(--ink3);
  padding-top:20px;border-top:1px solid var(--border)}

/* ---------- index grid ---------- */
.search{display:flex;align-items:center;gap:12px;margin:36px 0 26px;background:#fff;
  border:1px solid var(--border2);border-radius:var(--r-full);padding:13px 22px;
  box-shadow:var(--sh-sm);max-width:520px}
.search svg{width:19px;height:19px;color:var(--ink3);flex:none}
.search input{border:0;outline:0;font-family:var(--sans);font-size:15.5px;
  width:100%;color:var(--ink);background:transparent}
.grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(290px,1fr));
  gap:22px;padding-bottom:64px}
.card{display:flex;flex-direction:column;background:#fff;border:1px solid var(--border2);
  border-radius:var(--r-lg);padding:24px;text-decoration:none;color:var(--ink);
  box-shadow:var(--sh-sm);transition:transform .22s var(--ease),box-shadow .22s var(--ease),border-color .22s var(--ease)}
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.card-cls{font-family:var(--mono);font-size:11px;letter-spacing:.06em;text-transform:uppercase;
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.card h3{font-size:21px;letter-spacing:-.02em;margin-bottom:10px}
.bn{font-family:var(--mono);font-size:12.5px;color:var(--ink3);font-weight:400}
.card-s{font-size:14.5px;color:var(--ink2);line-height:1.55;flex:1}
.card .tags{margin-top:16px}
.nores{color:var(--ink3);padding:20px 0 64px}
/* .card sets display:flex, which outranks the UA rule for [hidden] — without this
   the search filter sets the attribute but every card stays on screen. */
[hidden]{display:none!important}

/* ---------- footer ---------- */
.foot{background:var(--bg1);border-top:1px solid var(--border);padding:34px 0 44px}
.foot-d{font-size:13.5px;color:var(--ink3);line-height:1.6;max-width:75ch;margin-bottom:14px}
.foot-d strong{color:var(--ink2)}
.foot-m{font-family:var(--mono);font-size:12px;color:var(--ink3)}
.updbadge{position:fixed;left:50%;transform:translateX(-50%);bottom:22px;z-index:80;
  background:var(--turq-strong);color:#fff;border:0;border-radius:var(--r-full);
  padding:12px 22px;font-family:var(--sans);font-size:14px;font-weight:500;
  cursor:pointer;box-shadow:0 6px 20px rgba(10,133,126,.35)}

/* ---------- responsive ---------- */
@media (max-width:920px){
  .cols{grid-template-columns:1fr;gap:0;padding-top:28px}
  .toc{position:static;margin-bottom:32px;background:var(--bg1);
    border:1px solid var(--border);border-radius:var(--r-md);padding:18px 20px}
  .toc ol{columns:2;column-gap:20px}
}
@media (max-width:560px){
  body{font-size:16px}
  .wrap{padding:0 18px}
  .hero{padding:32px 0 30px}
  .toc ol{columns:1}
  .glance{padding:20px}
  .dl-row{grid-template-columns:1fr;gap:2px}
  .tb nav{gap:14px;font-size:13.5px}
}
@media (prefers-reduced-motion:reduce){
  *{animation:none!important;transition:none!important}
  html{scroll-behavior:auto}
}
@media print{
  .topbar,.disc,.toc,.foot,.search,.updbadge{display:none!important}
  .cols{grid-template-columns:1fr;padding-top:0}
  body{font-size:11pt}
  .sec{page-break-inside:avoid}
}